Oral Care

Best-in-class for gum disease prevention

Dental products are specifically developed to combat harmful bacteria as well as to provide clean, fresh breath. Many studies demonstrated that oral care products containing Triclosan are significantly more effective than other commercially available products without Triclosan (Niles et al.2005, Davies et al. 2004, Niederman 2005). Due to its excellent antimicrobial activity and compatibility with a broad range of raw materials used in oral care formulations, Triclosan has proven to be an excellent agent for gum disease prevention (Sreenivasan & Gaffar, 2008) when used in toothpastes, combating the bacteria that are responsible for oral diseases such as gingivitis or periodontitis, when compared to other technologies. Despite its effectiveness against oral pathogens, Triclosan has no negative impact on the composition of the resident oral microflora – as many long-term studies in recent decades have shown (Fine et al., 1998).

Oral Care_BactericidalActivity

Figure 1:
Bactericidal activity of Triclosan on hydroxyapatite discs. Test organism: Actinomyces viscosus. (BASF. test performed in accordance to in-vitro biofilm model described by Guggenheim (Guggenheim et al., 2001).

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Anti-inflammatory effect of Triclosan

Another important feature of Triclosan in oral care applications is its
anti-inflammatory effect, which has been
proven in various studies. The dual functionality of Triclosan (antimicrobial and anti-inflammatory) has a positive effect on the prevention of gum diseases (Sreenivasan & Gaffar, 2008).

 

Proven in tests and studies

The beneficial effects of Triclosan in toothpastes and mouth rinses have been proven in in-vitro lab tests (see Figure 1) according to the method developed by Bernhard Guggenheim (Guggenheim et al. 2001) and have also been researched in various clinical studies on volunteers under in-use conditions. Numerous studies, many of them being long-term studies, showed that the use of dentifrices containing Triclosan significantly reduce plaque accumulation and maintain gingival health (Lorenz et al. 2002, Davies et al. 2004, Svatun et al. 1993). Furthermore, in terms of oral health benefits and control of bad breath, studies have shown that oral care products containing Triclosan are superior to conventional products without Triclosan (Mann et al. 2001).

 

Triclosan is the only active ingredient that combines strong antimicrobial activity with anti-inflammatory efficacy and excellent compatibility in complex formulations. Triclosan and Chlorhexidine have comparable antimicrobial activities, but Chlorhexidine is predominantly utilized in professional treatments under controlled conditions rather than in consumer care applications due to its side effect of tooth staining and limited compatibility with some raw materials usually used in toothpaste formulations.
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